Immune mechanisms underpinning remission of allergy
2021 AIFA Food Allergy Research Grant of $40,000
Professor Mimi Tang, Murdoch Children's Research Institute, Melbourne.
This project aims to decipher immune pathways supporting long-lasting remission of allergy, which will facilitate development of effective long-term treatments.
Clinical remission of allergy may be long-lasting or transient. Peanut oral immunotherapy alone (OIT) or in combination with probiotic (Probiotic Peanut Oral Immunotherapy or PPOIT) have both been shown to induce remission. PPOIT-induced remission was shown to last up to 4 years in 70% of initial responders, whereas OIT-induced remission was lost in two thirds (67%) of responders by 12 months after treatment. The immune changes underpinning remission and long-lasting remission remain unknown.
Immune responses are determined by networks of proteins/genes working together in a coordinated fashion. Previous studies have interrogated selected genes and pathways, generating an oversimplified and incomplete picture of underlying mechanisms.
A systems biology approach is needed to decipher the complex immune processes driving remission, and their coordinated inter-relationships. The aim of this project is to profile molecular and cellular changes associated with long-lasting versus transient remission, to identify specific changes leading to long-lasting remission. Findings will provide vital new knowledge that accelerates the path to finding a long-term treatment for peanut allergy.